Meet The Team
Dr. David Malkin. Senior Staff Oncologist, Senior Scientist
Dr. Malkin received his medical degree from the University of Toronto in 1984, and completed his residency in pediatrics and pediatric hematology/oncology at The Hospital for Sick Children in Toronto. After completing post-doctoral research training in molecular genetics at Massachusetts General Hospital, Harvard University, he returned to Canada to accept a position as a pediatric oncologist and a Senior Scientist at The Hospital for Sick Children in Toronto. Dr. Malkin’s research program focuses on genetic and genomic mechanisms of childhood cancer susceptibility which he has explored particularly in the context of TP53 and Li-Fraumeni syndrome. Recently, his work has addressed the application of genomics to develop rational clinical surveillance and treatment guidelines for children and adults at genetic ‘high risk’ for cancer.
Dr. Nish Patel, Senior Research Associate
After completion of his PhD at the Hospital for Sick Children and the University of Toronto in 2006, Dr. Patel did his post-doctoral research training at Harvard Medical School and the Children’s Hospital in Boston. He then returned to the Hospital for Sick Children as a Senior Research Associate in 2013. Dr. Patel has extensive expertise in cancer cell biology, drug development using phage-display technology, and drug validation by high throughput and high content screens. The primary focus of his research is the quantitative investigation of the signalling involved in cell growth and cell size regulation in normal and malignant cells.
Dr. Kafri completed his PhD in 2006 at the Weizmann Institute of Science in Israel. He subsequently completed his post-doctoral research training at Harvard Medical School before accepting a position as a Scientist in the Cell Biology Programme at The Hospital for Sick Children in 2013. The primary focus of the lab is to decipher how the regulation of mTORC1 activity is programmed to specify the precisely appropriate response. More specifically, Dr. Kafri’s lab is investigating the roles of mTORC1 in the quantitative specification of cell size. A distinction in our lab’s research is the integration of molecular biology with novel quantitative approaches. Over the past years, Dr. Kafri and his team have developed new data-analysis methods to interpret multivariate single cell measurements.
Dr. Sangeetha Paramathas
Dr. Nicholas Fisher
Dr. Miriam Ginzberg
PhD Graduate Student
PhD Graduate Student
Research Technologist II