mTORC1: a molecular lead towards cancer prevention

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Can one single mechanism prevent cancers that are mechanistically diverse?

"All happy families are alike; each unhappy family is unhappy in its own way." (Tolstoy).  And so it is with cancer. Each and every cancer becomes cancer in its own way. And yet - studies have identified a persistent association of diminished cancer risk with conditions of inhibited mTORC1 activity. Using LFS as a case in point, we seek to understand how mTORC1 inhibition prevents cancers that are caused by mutant p53  ​​